Medical Affairs

Innoviva Specialty Therapeutics has created this website as a tool for healthcare professionals in the United States. The information presented on this platform is solely for informational purposes and is not meant to advertise or endorse the use of any particular product.

Publications & Presentations

Information provided in these publications, posters and presentations is intended for scientific review by medical professionals. This information is not considered medical advice and is not intended to promote the sale of any drug product.

For more information on GIAPREZA, including important safety information, please visit www.GIAPREZA.com.

For more information on XERAVA, including important safety information, please visit www.XERAVA.com.

For more information on XACDURO, including important safety information, please visit www.XACDURO.com.

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GIAPREZA®

Effects of angiotensin II in the management of perioperative hypotension in kidney transplant recipients

Resource Type

Publication

Author Name

Andrews

Date Published

July 2023

XACDURO®

Sulbactam-durlobactam: A Step Forward in Treating Carbapenem-Resistant Acinetobacter baumannii (CRAB) Infections

Resource Type

Publication

Author Name

Watkins

Date Published

May 2023

XERAVA®

In vitro activity of eravacycline and comparator agents against bacterial pathogens isolated from patients with cancer

Resource Type

Publication

Author Name

Rolston

Date Published

March 2023

XERAVA®

Clinical Outcomes of Eravacycline in Patients Treated Predominately for Carbapenem-Resistant Acinetobacter baumannii

Resource Type

Publication

Author Name

Alosaimy

Date Published

October 2022

GIAPREZA®

A double-blind randomised feasibility trial of angiotensin-2 in cardiac surgery

Resource Type

Publication

Author Name

Coulson

Date Published

September 2022

GIAPREZA®

Angiotensin II enhances bacterial clearance via myeloid signaling in a murine sepsis model

Resource Type

Publication

Author Name

Leisman

Date Published

August 2022

XERAVA®

Assessing the Real-world Clinical Outcomes of Patients Treated with Eravacycline for Complicated Intra-abdominal Infections

Resource Type

Publication

Author Name

Alosaimy

Date Published

April 2022

XERAVA®

A retrospective, multicentre evaluation of eravacycline utilisation in community and academic hospitals

Resource Type

Publication

Author Name

Hobbs

Date Published

November 2021

XERAVA®

Evaluation of Predictors of Clinical Success in Patients Treated with Eravacycline for Various Infections

Resource Type

Publication

Author Name

Alosaimy

Date Published

October 2021

XERAVA®

In Vitro Activity of Eravacycline Against Clinically Significant Bacteria Isolated from Patients with Cancer

Resource Type

Publication

Author Name

Gerges

Date Published

October 2021

GIAPREZA®

Serum renin and major adverse kidney events in critically ill patients: a multicenter prospective study

Resource Type

Publication

Author Name

Flannery

Date Published

August 2021

GIAPREZA®

Angiotensin II for Near Drowning: A Case Series

Resource Type

Publication

Author Name

Smith

Date Published

May 2021

GIAPREZA®

Commentary: Angiotensin II: Expanding the rescue options for vasoplegia

Resource Type

Publication

Author Name

Augoustides

Date Published

April 2021

GIAPREZA®

Commentary: Is angiotensin II a game changer for vasoplegia after cardiac surgery, or is the jury still out?

Resource Type

Publication

Author Name

Chatterjee

Date Published

March 2021

XACDURO®

In Vitro Antibacterial Activity and In Vivo Efficacy of Sulbactam-Durlobactam against Pathogenic Burkholderia Species

Resource Type

Publication

Author Name

Papp-Wallace

Date Published

February 2021

GIAPREZA®

Intraoperative Use of Angiotensin II for Severe Vasodilatory Shock During Liver Transplantation: A Case Report

Resource Type

Publication

Author Name

Running

Date Published

February 2021

GIAPREZA®

A Multicenter Observational Cohort Study of Angiotensin II in Shock

Resource Type

Publication

Author Name

Smith

Date Published

November 2020

XERAVA®

Tomefa E Asempa, Sergey Izmailyan, Kenneth Lawrence, David P Nicolau

Resource Type

Publication

Author Name

Alosaimy

Date Published

October 2020

XERAVA®

A Real-World Assessment of Clinical Outcomes and Safety of Eravacycline: A Novel Fluorocycline

Resource Type

Publication

Author Name

Hise

Date Published

October 2020

GIAPREZA®

Angiotensin II Administration in Patients With COVID-19 Shock

Resource Type

Publication

Author Name

Ofosu-Barko

Date Published

October 2020

XERAVA®

In vitro activity of eravacycline against common ribotypes of Clostridioides difficile

Resource Type

Publication

Author Name

Bassères

Date Published

October 2020

XERAVA®

In vitro activity of eravacycline compared with tigecycline against carbapenem-resistant Enterobacteriaceae

Resource Type

Publication

Author Name

Clark

Date Published

September 2020

XERAVA®

Eravacycline, a novel tetracycline derivative, does not induce Clostridioides difficile infection in an in vitro human gut model

Resource Type

Publication

Author Name

Buckley

Date Published

September 2020

GIAPREZA®

Vasopressor-Refractory Shock From Clozapine Overdose Treated With Synthetic Angiotensin II Infusion

Resource Type

Publication

Author Name

Wieruszewski

Date Published

September 2020

GIAPREZA®

Angiotensin II and Vasoplegia in Cardiac Surgery: Paradigm Changer or Costly Contender?

Resource Type

Publication

Author Name

Chow

Date Published

September 2020

GIAPREZA®

Angiotensin II in Post Cardiopulmonary Bypass Vasoplegia – The Experience So Far

Resource Type

Publication

Author Name

Cutler

Date Published

September 2020

GIAPREZA®

Angiotensin II Infusion for Shock: A Multicenter Study of Postmarketing Use

Resource Type

Publication

Author Name

Wieruszewski

Date Published

August 2020

GIAPREZA®

Impaired angiotensin II type 1 receptor signaling contributes to sepsis-induced acute kidney injury

Resource Type

Publication

Author Name

Leisman

Date Published

August 2020

GIAPREZA®

Angiotensin II for Critically Ill Patients With Shock After Heart Transplant

Resource Type

Publication

Author Name

Cutler

Date Published

August 2020

XERAVA®

Antibiotic Susceptibility of NDM-Producing Enterobacterales Collected in the United States in 2017 and 2018

Resource Type

Publication

Author Name

Lutgring

Date Published

August 2020

GIAPREZA®

Successful use of angiotensin II for vasoplegia after thoracoabdominal aortic aneurysm repair

Resource Type

Publication

Author Name

Chatterjee

Date Published

August 2020

GIAPREZA®

Treatment of Renin-Angiotensin-Aldosterone System Dysfunction With Angiotensin II in High-Renin Septic Shock

Resource Type

Publication

Author Name

Chow

Date Published

August 2020

XERAVA®

In Vitro Activities of Eravacycline and Other Antimicrobial Agents against Human Mycoplasmas and Ureaplasmas

Resource Type

Publication

Author Name

Waites

Date Published

July 2020

GIAPREZA®

Renin and Survival in Patients Given Angiotensin II for Catecholamine-Resistant Vasodilatory Shock

Resource Type

Publication

Author Name

Bellomo

Date Published

July 2020

GIAPREZA®

Use of Angiotensin II in Severe Vasoplegia After Left Pneumonectomy Requiring Cardiopulmonary Bypass: A Renin Response Analysis

Resource Type

Publication

Author Name

Trethowan

Date Published

July 2020

GIAPREZA®

Angiotensin II for the Treatment of COVID-19–Related Vasodilatory Shock

Resource Type

Publication

Author Name

Chow

Date Published

July 2020

GIAPREZA®

Angiotensin II for the treatment of septic shock in a neutropenic patient with T-cell acute lymphoblastic leukaemia

Resource Type

Publication

Author Name

Bui

Date Published

June 2020

XACDURO®

In vitro activity of sulbactam/durlobactam against global isolates of carbapenem-resistant Acinetobacter baumannii

Resource Type

Publication

Author Name

Seifert

Date Published

June 2020

XERAVA®

Real-world utilization of eravacycline in the outpatient setting

Resource Type

Publication

Author Name

Hwang

Date Published

May 2020

GIAPREZA®

Unexpected BP Sensitivity to Angiotensin II in a Patient With Coronavirus Disease 2019, ARDS, and Septic Shock

Resource Type

Publication

Author Name

Wang

Date Published

April 2020

XACDURO®

In vitro activity of sulbactam/durlobactam against clinical isolates of Acinetobacter baumannii collected in China

Resource Type

Publication

Author Name

Yang

Date Published

April 2020

GIAPREZA®

Effective Use of Angiotensin II in Coronavirus Disease 19–Associated Mixed Shock State: A Case Report

Resource Type

Publication

Author Name

Bobeck

Date Published

April 2020

GIAPREZA®

COVID-19 and the RAAS—a potential role for angiotensin II?

Resource Type

Publication

Author Name

Busse

Date Published

April 2020

XERAVA®

Early Experience With Eravacycline for Complicated Infections

Resource Type

Publication

Author Name

Alosaimy

Date Published

March 2020

GIAPREZA®

Angiotensin II for the treatment of distributive shock in the intensive care unit: A US costeffectiveness analysis

Resource Type

Publication

Author Name

Busse

Date Published

March 2020

XERAVA®

In Vitro Activity of Eravacycline against Gram-Positive Bacteria Isolated in Clinical Laboratories Worldwide from 2013 to 2017

Resource Type

Publication

Author Name

Morrissey

Date Published

February 2020

GIAPREZA®

Angiotensin I and angiotensin II concentrations and their ratio in catecholamine-resistant vasodilatory shock

Resource Type

Publication

Author Name

Bellomo

Date Published

February 2020

GIAPREZA®

Another Role for Angiotensin II?: Vasopressin-Refractory Shock After Pheochromocytoma Resection: A Case Report

Resource Type

Publication

Author Name

Hylton

Date Published

January 2020

XERAVA®

Real-World Use of Eravacycline: A Case Series

Resource Type

Publication

Author Name

Lunsted

Date Published

December 2019

XERAVA®

Eravacycline for the treatment of complicated intra-abdominal infections

Resource Type

Publication

Author Name

Montravers

Date Published

October 2019

XERAVA®

Activity of Eravacycline Against Contemporary Gram-negative Clinical Isolates from New York City Hospitals

Resource Type

Publication

Author Name

Khan

Date Published

October 2019

XERAVA®

Comparative evaluation of ETEST® ERV* bioMérieux with the CLSI broth microdilution method for Eravacycline MIC determination

Resource Type

Publication

Author Name

SAUVONNET

Date Published

October 2019

XERAVA®

Novel Therapeutic Options for the Treatment of Multi-Drug Resistant Achromobacter Respiratory Infections

Resource Type

Publication

Author Name

Canonica

Date Published

October 2019

XERAVA®

Multicenter Evaluation of Eravacycline MIC Results for Enterobacteriaceae Using MicroScan Dried Gram Negative MIC Panels

Resource Type

Publication

Author Name

Traczewski

Date Published

October 2019

XERAVA®

Eravacycline: a new treatment option for complicated intra-abdominal infections in the age of multidrug resistance

Resource Type

Publication

Author Name

Solomkin

Date Published

October 2019

XERAVA®

Assessment of the Physical Compatibility of Eravacycline and Common Parenteral Drugs During Simulated Y-site Administration

Resource Type

Publication

Author Name

Avery

Date Published

October 2019

GIAPREZA®

Angiotensin II in Decompensated Cirrhosis Complicated by Septic Shock

Resource Type

Publication

Author Name

Coleman

Date Published

September 2019

Zoliflodacin

Determination of MIC Quality Control Ranges for the Novel Gyrase Inhibitor Zoliflodacin

Resource Type

Publication

Author Name

Miller

Date Published

August 2019

GIAPREZA®

Synthetic Human Angiotensin II in Pediatric Patients With Vasodilatory Shock: A Report on Two Patients

Resource Type

Publication

Author Name

Bailey

Date Published

August 2019

GIAPREZA®

Successful Treatment of Antihypertensive Overdose Using Intravenous Angiotensin II

Resource Type

Publication

Author Name

Carpenter

Date Published

July 2019

XERAVA®

Comparative evaluation of Eravacycline MIC determination with the new ETEST® ERV* and CLSI broth microdilution method

Resource Type

Publication

Author Name

PILLON

Date Published

June 2019

GIAPREZA®

Sensitivity to angiotensin II dose in patients with vasodilatory shock: a prespecified analysis of the ATHOS-3 trial

Resource Type

Publication

Author Name

Ham

Date Published

June 2019

XERAVA®

Multi-Site Evaluation of Eravacycline MIC Test Strip (MTS) Compared To Broth Microdilution MICs

Resource Type

Publication

Author Name

OLESKY

Date Published

May 2019

GIAPREZA®

Synthetic Human Angiotensin II for Postcardiopulmonary Bypass Vasoplegic Shock

Resource Type

Publication

Author Name

Wieruszewski

Date Published

May 2019

XERAVA®

Multicenter Evaluation of Eravacycline MIC Results for E. coli Using MicroScan Dried Gram Negative MIC Panels

Resource Type

Publication

Author Name

Garner

Date Published

April 2019

GIAPREZA®

Use of Angiotensin II for Vasoplegic Shock in a Combined Heart and Liver Transplant Recipient with Systolic Anterior Motion Physiology

Resource Type

Publication

Author Name

Wieruszewski

Date Published

March 2019

XERAVA®

Eravacycline: A Review in Complicated Intra-Abdominal Infections

Resource Type

Publication

Author Name

Scott

Date Published

February 2019

Zoliflodacin

Single-Dose Pharmacokinetics, Excretion, and Metabolism of Zoliflodacin, a Novel Spiropyrimidinetrione Antibiotic, in Healthy Volunteers

Resource Type

Publication

Author Name

O’Donnell

Date Published

December 2018

GIAPREZA®

Angiotensin II Use in Refractory Multisystem Shock: A Case Report

Resource Type

Publication

Author Name

Ahmed

Date Published

November 2018

Zoliflodacin

Single-Dose Zoliflodacin (ETX0914) for Treatment of Urogenital Gonorrhea

Resource Type

Publication

Author Name

Taylor

Date Published

November 2018

GIAPREZA®

Angiotensin in ECMO patients with refractory shock

Resource Type

Publication

Author Name

Ostermann

Date Published

November 2018

GIAPREZA®

Angiotensin converting enzyme defects in shock: implications for future therapy

Resource Type

Publication

Author Name

Chawla

Date Published

October 2018

GIAPREZA®

When All Else Fails: Novel Use of Angiotensin II for Vasodilatory Shock: A Case Report

Resource Type

Publication

Author Name

Chow

Date Published

October 2018

GIAPREZA®

FDA Approval of Angiotensin II for the Treatment of Hypotension in Adults with Distributive Shock

Resource Type

Publication

Author Name

Senatore

Date Published

August 2018

XERAVA®

In vitro susceptibility of β-lactamase-producing carbapenem-resistant Enterobacteriaceae (CRE) to eravacycline

Resource Type

Publication

Author Name

Zhang

Date Published

June 2018

XERAVA®

Pharmacokinetics and Comprehensive Analysis of the Tissue Distribution of Eravacycline in Rabbits

Resource Type

Publication

Author Name

Petraitis

Date Published

June 2018

GIAPREZA®

Outcomes in Patients with Vasodilatory Shock and Renal Replacement Therapy Treated with Intravenous Angiotensin II

Resource Type

Publication

Author Name

Tumlin

Date Published

June 2018

XERAVA®

Evaluation of the In Vitro Activity of Eravacycline against a Broad Spectrum of Recent Clinical Anaerobic Isolates

Resource Type

Publication

Author Name

Snydman

Date Published

May 2018

XERAVA®

In-vitro activity of the novel fluorocycline eravacycline against carbapenem non-susceptible Acinetobacter baumannii

Resource Type

Publication

Author Name

Seifert

Date Published

January 2018

GIAPREZA®

The effect of angiotensin II on blood pressure in patients with circulatory shock: a structured review of the literature

Resource Type

Publication

Author Name

Busse

Date Published

December 2017

XACDURO®

Acinetobacter baumannii OmpA Is a Selective Antibiotic Permeant Porin

Resource Type

Publication

Author Name

Iyer

Date Published

December 2017

XACDURO®

Kinetics of Sulbactam Hydrolysis by β-Lactamases, and Kinetics of β-Lactamase Inhibition by Sulbactam

Resource Type

Publication

Author Name

Shapiro

Date Published

November 2017

XERAVA®

In Vitro Activity of Eravacycline and comparator antimicrobials against 143 recent strains of Bacteroides species

Resource Type

Publication

Author Name

Citron,

Date Published

October 2017

XERAVA®

Impact of Meal Timing on Eravacycline Exposure During the Oral Portion of an IV to Oral Transition Dosing Regimen

Resource Type

Publication

Author Name

Horn

Date Published

October 2017

XACDURO®

Reversibility of Covalent, Broad-Spectrum Serine β-Lactamase Inhibition by the Diazabicyclooctenone ETX2514

Resource Type

Publication

Author Name

Shapiro

Date Published

August 2017

GIAPREZA®

Angiotensin II for the Treatment of Vasodilatory Shock

Resource Type

Publication

Author Name

Khanna

Date Published

August 2017

GIAPREZA®

Clinical Experience With IV Angiotensin II Administration: A Systematic Review of Safety

Resource Type

Publication

Author Name

Busse

Date Published

August 2017

XERAVA®

In Vivo Pharmacodynamic Target Assessment of Eravacycline against Escherichia coli in a Murine Thigh Infection Model

Resource Type

Publication

Author Name

Zhao

Date Published

July 2017

XERAVA®

A Divergent Route to Eravacycline

Resource Type

Publication

Author Name

Zhang

Date Published

December 2016

Zoliflodacin

In vitro growth of multidrug-resistant Neisseria gonorrhoeae isolates is inhibited by ETX0914, a novel spiropyrimidinetrione

Resource Type

Publication

Author Name

Papp

Date Published

July 2016

XERAVA®

In Vitro Activity of Eravacycline against Carbapenem-Resistant Enterobacteriaceae and Acinetobacter baumannii

Resource Type

Publication

Author Name

Livermore

Date Published

June 2016

XERAVA®

Review of Eravacycline, a Novel Fluorocycline Antibacterial Agent

Resource Type

Publication

Author Name

Zhanel

Date Published

April 2016

Zoliflodacin

Effect of Susceptibility Testing Conditions on the In Vitro Antibacterial Activity of ETX0914

Resource Type

Publication

Author Name

Giacobbe

Date Published

March 2016

Zoliflodacin

Update on Treatment Options for Gonococcal Infections

Resource Type

Publication

Author Name

Lancaster

Date Published

September 2015

Zoliflodacin

In Vitro Antibacterial Activity of AZD0914 against Human Mycoplasmas and Ureaplasmas

Resource Type

Publication

Author Name

Waites

Date Published

May 2015

XACDURO®

Molecular Mechanisms of Sulbactam Antibacterial Activity and Resistance Determinants in Acinetobacter baumannii

Resource Type

Publication

Author Name

Penwell

Date Published

February 2015

Zoliflodacin

In Vitro Activity of AZD0914, a Novel DNA Gyrase Inhibitor, against Chlamydia trachomatis and Chlamydia pneumoniae

Resource Type

Publication

Author Name

Kohlhoff

Date Published

November 2014

GIAPREZA®

Intravenous angiotensin II for the treatment of high-output shock (ATHOS trial): a pilot study

Resource Type

Publication

Author Name

Chawla

Date Published

October 2014

Zoliflodacin

Novel DNA Gyrase Inhibiting Spiropyrimidinetriones with a Benzisoxazole Scaffold: SAR and in Vivo Characterization

Resource Type

Publication

Author Name

Basarab

Date Published

October 2014

XERAVA®

Antibacterial Activity of Eravacycline (TP-434), a Novel Fluorocycline, against Hospital and Community Pathogens

Resource Type

Publication

Author Name

Sutcliffe

Date Published

November 2013

XERAVA®

Process R&D of Eravacycline: The First Fully Synthetic Fluorocycline in Clinical Development

Resource Type

Publication

Author Name

Ronn

Date Published

April 2013

XERAVA®

Target- and Resistance-Based Mechanistic Studies with TP-434, a Novel Fluorocycline Antibiotic

Resource Type

Publication

Author Name

Grossman

Date Published

February 2012

Zoliflodacin

Inhibition of Neisseria gonorrhoeae Type II Topoisomerases by the Novel Spiropyrimidinetrione AZD0914

Resource Type

Publication

Author Name

Kern

Date Published

November 2023